Significance of Insilco Approaches in Finding Novel Biomolecules Challenging Newly Emerging, Resurging, Deliberately Emerging Global Outbreaks

Pandemics are large-scale outbreaks of contagious disease that can significantly raise ill health and promote death. Pandemics can spread through, wide range of geographical areas across the globe and capable of disrupting social and economic status of the countries affected. With the scientific testimony available it is evidenced that the rate of occurrence of pandemics has been drastically increased over the last two decades and presently witnessing the impact of COVID-19 disease globally. Anthropogenic activities such as urbanization conditions, increased global travel, abnormal land usage, exploitation of natural environment, are some of the significant causative factors that promote the rate of occurrence of pandemics. Rapid spread of SARS-CoV-2 virus highlighted the importance such as, be ready for any imminent event, need of detecting new bacterial and viral pathogens at initial stages of contagion and focus on the risk elements that promote the occurrence and spread of the outbreaks to humankind. It is evidenced from the literature that, there is a great demand to institute the methodological process using smart approaches such as Insilco based studies to investigate the emergence of future pandemics. Globally there is a great demand for the robust and efficient procedures to develop novel biomolecule in quick period. With this significance, the present paper aimed to survey the occurrence of global pandemics and the applications of Insilco methods in identifying newer routes to develop novel biomolecules in challenge the existing, newly emerging, resurging, deliberately emerging global outbreaks. © 2022 Published by ISRES Publishing: www.isres.org.

Podophyllotoxin: History, Recent Advances and Future Prospects.

Podophyllotoxin, along with its various derivatives and congeners are widely recognized as broad-spectrum pharmacologically active compounds. Etoposide, for instance, is the frontline chemotherapeutic drug used against various cancers due to its superior anticancer activity. It has recently been redeveloped for the purpose of treating cytokine storm in COVID-19 patients. Podophyllotoxin and its naturally occurring congeners have low bioavailability and almost all these initially discovered compounds cause systemic toxicity and development of drug resistance. Moreover, the production of synthetic derivatives that could suffice for the clinical limitations of these naturally occurring compounds is not economically feasible. These challenges demanded continuous devotions towards improving the druggability of these drugs and continue to seek structure-optimization strategies. The discovery of renewable sources including microbial origin for podophyllotoxin is another possible approach. This review focuses on the exigency of innovation and research required in the global R&D and pharmaceutical industry for podophyllotoxin and related compounds based on recent scientific findings and market predictions.